Henry was a noted scientist in the United States when he was selected to serve as the first Secretary, or chief executive officer, of the new
Smithsonian Institution in 1846. He served for 30 years, developing the new museum as a center for research, publications, and international exchange. During his tenure, the Smithsonian provided important support for scientists by coordinating and funding research, publishing original studies, and facilitating communication among scientists in the United States and abroad. He lived
with his family in the
Smithsonian Castle until his death in 1878.